Supplementary Table S3 from Consistent Metabolomic and Genetic Evidence Supports Acisoga as a Key Contributor to Colorectal Neoplasia Progression

<jats:p>&lt;p&gt;Supplementary Table S3. Sensitivity analyses of Acisoga associations with CRC risk in the EPIC cohort stratified by tumour site, sex, and dietary factors. Odds ratios (OR) and 95% confidence intervals (CI) for CRC per 1 standard deviation (SD) increase in log-transformed metabolite levels are shown for three metabolic features corresponding to Acisoga-related ions and 248.0997@0.6454001. d stratification Sex, tumour anatomical site (proximal and distal colon), and tertiles (T1–T3) of dietary factors including red/processed meat intake, dietary fiber intake, and vegetable intake. Further models additionally adjusted for vegetable intake and dietary fiber intake. P-values for interaction were obtained from multiplicative interaction terms between metabolite levels and the corresponding stratification variable.&lt;/p&gt;</jats:p>