Figure 6 from SET1B Drives Sustained HIF Activity and Disease Progression in Clear-Cell Renal Cell Carcinoma

<jats:p>&lt;p&gt;Model for the role of SET1B in ccRCC. In ccRCC, HIF2 is constitutively active because of the loss of VHL protein. SET1B is recruited to HIF target genes by the HIF complex, in which it plays a critical role in initiating and sustaining HIF transcription. This is achieved through its H3K4me3 activity and its interaction with the RNA Pol II complex. The enhanced HIF2 transcription leads to increased angiogenesis, metastasis, and disease progression.&lt;/p&gt;</jats:p>